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Alaa A Gad

Alaa A Gad

Cairo University, Egypt

Title: Study of the role of IL-17F gene polymorphism in the development of immune thrombocytopenia among the Egyptian children

Biography

Biography: Alaa A Gad

Abstract

Background: Interleukin 17F (IL-17F) is a pro-inflammatory cytokine that is recently proved to have a crucial role in the emergence of autoimmune diseases; it induces the expression of various cytokines, chemokines and adhesion molecules. IL-17F polymorphism is subsequently related to enhanced IL-17F expression and activity; which may result in susceptibility to many autoimmune diseases including primary immune thrombocytopenia (PIT).
Aim of the study: This case- control study aimed to investigate the possible association between IL-17F gene single nucleotide polymorphism (SNP) at rs 7488A/G and PIT susceptibility in Egyptian pediatric patients.
 
Subjects and Methods: A total of 50 children with PIT with mean age of 7 years, together with 50 age and sex matched healthy controls were enrolled in the study for evaluation. Polymerase chain reaction- restriction fragment length
polymorphism (PCR-RFLP) was used for detection of IL-17F polymorphism at rs7488A/G.
 
Results: Regarding the genotypes distribution, the frequencies of the AA, AG and GG genotypes were 96, 2, and 2% in PIT patients and 90, 10 and 0% in the control group respectively. The A and G allele frequencies were 97 and 3%
in the patients group versus 95 and 5% in the control group. There was no significant difference in either genotypes or allelic distribution between PIT patients and the controls.
 
Conclusion: our study suggests that IL17F gene polymorphism at rs7488A/G may not contribute to the susceptibility in development of primary immune thrombocytopenia in the Egyptian children.